Until ten years ago, geneticist Don Tillman had never had a second date. Then he developed The Wife Project and met Rosie, 'the world's most incompatible woman'. Now, having survived 3,653 days of marriage, Don's life-contentment graph, recently at its highest point, is curving downwards.
Don and Rosie's ten-year-old son, Hudson, is having trouble at school: his teachers say he isn't fitting in with the other kids. Rosie is battling Judas at work, and Don is in hot water after the Genetics Lecture Outrage.